Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:967973 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
967973968800828HAD hydrolase IIB familyQuickGO ontologyBLASTP
969127970107981PTS system mannosefructosesorbose family IIB componentQuickGO ontologyBLASTP
970158970961804PTS system mannosefructosesorbose family IIC componentQuickGO ontologyBLASTP
970981971892912PTS system mannosefructosesorbose family IID componentQuickGO ontologyBLASTP
972063972437375hypothetical proteinBLASTP
972821973168348hypothetical protein
973394974311918polysaccharide deacetylase family proteinQuickGO ontologyBLASTP
974770975552783hypothetical proteinBLASTP
975809976750942hypothetical proteinBLASTP
9770259794392415glycosyl hydrolase family 2QuickGO ontologyBLASTP
980233981186954SCP-like extracellular family proteinQuickGO ontologyBLASTP
981315981461147hypothetical protein
9815139833241812ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
9833249851141791ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
985331985828498hypothetical proteinBLASTP
9858379874651629hypothetical proteinBLASTP
987834988118285arsenical resistance operon repressorQuickGO ontologyBLASTP
988237988635399arsenate reductase ArsCQuickGO ontologyBLASTP