Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:817295 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8172958223555061Fibronectin type III domain proteinQuickGO ontologyBLASTP
822530822661132hypothetical protein
8228278238401014phospho-2-dehydro-3-deoxyheptonate aldolaseQuickGO ontologyBLASTP
82396182501310533-dehydroquinate synthaseQuickGO ontologyBLASTP
82520682648012753-phosphoshikimate 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
8265448276171074chorismate synthaseQuickGO ontologyBLASTP
827786828079294chorismate mutaseQuickGO ontologyBLASTP
82825582834793hypothetical protein
828901829716816shikimate 5-dehydrogenaseQuickGO ontologyBLASTP
829970830473504shikimate kinaseQuickGO ontologyBLASTP
8305408309744353-dehydroquinate dehydratase type IIQuickGO ontologyBLASTP
830995831336342putative transcriptional regulatorQuickGO ontologyBLASTP
8315928326981107oxidoreductase FADFMN-bindingQuickGO ontologyBLASTP
833435833950516hypothetical proteinBLASTP
834077834409333transcriptional regulator PadR familyQuickGO ontologyBLASTP
834411835268858hypothetical proteinBLASTP
835480835974495hypothetical proteinBLASTP
836142836321180hypothetical proteinBLASTP
836447837337891ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
8373398385501212putative ABC transporter permease proteinQuickGO ontologyBLASTP
838665839654990choloylglycine hydrolaseQuickGO ontologyBLASTP
840440840922483transcriptional regulator AsnC familyQuickGO ontologyBLASTP
8409198420971179aminotransferase class IIIQuickGO ontologyBLASTP