Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:551513 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
551513552211699capsule chain length determinant proteinQuickGO ontologyBLASTP
552224552877654capsular polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
553078553746669capsular polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
5547745560031230UDP-glucoseGDP-mannose dehydrogenase familyQuickGO ontologyBLASTP
557181557780600bacterial transferase hexpeptide repeat proteinQuickGO ontologyBLASTP
5577965596881893heparinase IIIII-like proteinQuickGO ontologyBLASTP
5596995610781380putative capK proteinQuickGO ontologyBLASTP
5611065621761071glycosyl transferase group 1QuickGO ontologyBLASTP
5621785636441467putative polysaccharide transporter proteinQuickGO ontologyBLASTP
5636315648481218hypothetical protein
5648485659991152hypothetical protein
5660795672061128glycosyl transferase group 1QuickGO ontologyBLASTP
5672235685511329glycosyl transferase group 1QuickGO ontologyBLASTP
568563569444882glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
569550570119570dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
570133571017885dTDP-4-dehydrorhamnose reductaseQuickGO ontologyBLASTP
5710455720941050dTDP-glucose 46-dehydrataseQuickGO ontologyBLASTP
572270573190921UTP-glucose-1-phosphate uridylyltransferaseQuickGO ontologyBLASTP
573555574202648putative RNA polymerase sigma factorQuickGO ontologyBLASTP