Pre_GI Gene

Some Help

Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:381297 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3812973826791383amino acid permease family proteinQuickGO ontologyBLASTP
3830083843121305hypothetical proteinBLASTP
3845843859691386TldDPmbA family proteinQuickGO ontologyBLASTP
3859853873341350TldDPmbA family proteinQuickGO ontologyBLASTP
3876433892291587L-aspartate beta-decarboxylaseQuickGO ontologyBLASTP
389547390023477methylated-DNA-protein-cysteine S-methyltransferaseQuickGO ontologyBLASTP
3900723922462175ATP-dependent DNA helicase RecQQuickGO ontologyBLASTP
392334392462129hypothetical protein
392477393274798amidinotransferase family proteinQuickGO ontologyBLASTP
3934183948571440MATE efflux family proteinQuickGO ontologyBLASTP
395023395772750putative transcriptional activator tipAQuickGO ontologyBLASTP
395893396303411hypothetical proteinBLASTP
396319396723405hypothetical proteinBLASTP
396713396997285hypothetical protein
397006397377372hypothetical proteinBLASTP
397452398123672cyclic nucleotide-binding domain proteinQuickGO ontologyBLASTP
3990684018872820excinuclease ABC A subunitQuickGO ontologyBLASTP