Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:304000 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
304374304574201hypothetical proteinBLASTP
3046953060081314hypothetical proteinBLASTP
306226306522297hypothetical proteinBLASTP
306730307407678uracil-DNA glycosylaseQuickGO ontologyBLASTP
3077453102822538putative beta-N-acetylhexosaminidaseQuickGO ontologyBLASTP
310696312213151816S ribosomal RNAQuickGO ontologyBLASTP
312399315303290523S ribosomal RNAQuickGO ontologyBLASTP
3153563154731185S ribosomal RNAQuickGO ontologyBLASTP
31548531556076tRNA-PheQuickGO ontologyBLASTP
316026316493468antioxidant AhpCTSA familyQuickGO ontologyBLASTP
317140317886747peptidyl-prolyl cis-trans isomerase family proteinQuickGO ontologyBLASTP
318350319162813ABC-2 type transporter permease proteinQuickGO ontologyBLASTP
3191803203521173ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
3203663216491284glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
3216683229031236glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
3229173240981182ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
3242133256461434glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
325782326435654haloacid dehalogenase IA family proteinQuickGO ontologyBLASTP
3265183278671350Fe hydrogenaseQuickGO ontologyBLASTP