Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2920999 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29209992921952954putative maltosemaltodextrin ABC transporter permease proteinQuickGO ontologyBLASTP
292203929232651227putative maltosemaltodextrin ABC transporter maltosemaltodextrin-binding proteinQuickGO ontologyBLASTP
29237232924664942hypothetical proteinBLASTP
292469929258081110putative maltosemaltodextrin ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
292602729277451719iron hydrogenaseQuickGO ontologyBLASTP
292797129290411071butyrate kinaseQuickGO ontologyBLASTP
29290652929973909phosphate butyryltransferaseQuickGO ontologyBLASTP
293015629317571602hypothetical proteinBLASTP
293183329331581326hypothetical proteinBLASTP
29331252933982858conserved hypothetical protein TIGR00159QuickGO ontologyBLASTP
29341432935105963hypothetical protein
29351762935778603putative spore-cortex-lytic enzymeQuickGO ontologyBLASTP
29358102936670861pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
29366972937011315thioredoxinQuickGO ontologyBLASTP
293712829382971170isoaspartyl dipeptidaseQuickGO ontologyBLASTP
293846229400811620phosphoenolpyruvate-protein phosphotransferaseQuickGO ontologyBLASTP