Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2743942 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27439422744361420hypothetical proteinBLASTP
27443842745364981thiamin biosynthesis protein ThiIQuickGO ontologyBLASTP
27454102746039630stage II sporulation protein RQuickGO ontologyBLASTP
274610927469758674-diphosphocytidyl-2C-methyl-D-erythritol kinaseQuickGO ontologyBLASTP
274711127497352625cyanophycin synthetaseQuickGO ontologyBLASTP
27497222750558837cyanophycinaseQuickGO ontologyBLASTP
275064927522111563lysM domain proteinQuickGO ontologyBLASTP
27525712752807237hypothetical proteinBLASTP
27529702753857888peptidase family proteinQuickGO ontologyBLASTP
275405627550601005spore coat protein CotSQuickGO ontologyBLASTP
275516927562961128mannosyltransferase BQuickGO ontologyBLASTP
275647927575071029putative spore coat proteinQuickGO ontologyBLASTP
27575232758206684hypothetical proteinBLASTP
275821427592211008putative spore coat proteinQuickGO ontologyBLASTP
275935027604951146putative mannosyltransferaseQuickGO ontologyBLASTP
27607292761259531hypothetical proteinBLASTP
27614522761823372hypothetical proteinBLASTP
27619642762407444putative lipoproteinQuickGO ontologyBLASTP
276244227634701029ApbE family proteinQuickGO ontologyBLASTP
276359327647171125putative ethanolamine utilization protein EutHQuickGO ontologyBLASTP
27648802765209330PTS system lactosecellobiose-specific IIB componentQuickGO ontologyBLASTP
276543927668181380serine proteaseQuickGO ontologyBLASTP