Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2708929 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
270892927111632235helicase RecDTraA familyQuickGO ontologyBLASTP
271130027124361137N-acetylglucosamine-6-phosphate deacetylaseQuickGO ontologyBLASTP
271257227137471176S-adenosylmethionine synthetaseQuickGO ontologyBLASTP
2714178271426386tRNA-TyrQuickGO ontologyBLASTP
2714269271434476tRNA-ThrQuickGO ontologyBLASTP
2714370271445586tRNA-TyrQuickGO ontologyBLASTP
2714461271453676tRNA-ThrQuickGO ontologyBLASTP
2714555271463076tRNA-ValQuickGO ontologyBLASTP
2714635271472086tRNA-TyrQuickGO ontologyBLASTP
2714726271480176tRNA-ThrQuickGO ontologyBLASTP
27149662715610645hypothetical proteinBLASTP
27157162716246531putative sporulation protein YyaCQuickGO ontologyBLASTP
271628527173221038mbl proteinQuickGO ontologyBLASTP
27174132717664252stage III sporulation protein DQuickGO ontologyBLASTP
27177412718511771putative peptidaseQuickGO ontologyBLASTP
271862127196431023stage II sporulation protein DQuickGO ontologyBLASTP
271975527210201266UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
27210432721687645hypothetical proteinBLASTP
27218692722270402ATP synthase F1 epsilon subunitQuickGO ontologyBLASTP
272228627236831398ATP synthase F1 beta subunitQuickGO ontologyBLASTP
27236972724548852ATP synthase F1 gamma subunitQuickGO ontologyBLASTP
272461327261211509ATP synthase F1 alpha subunitQuickGO ontologyBLASTP
27261322726671540ATP synthase F1 delta subunitQuickGO ontologyBLASTP
27266742727153480ATP synthase F0 B subunitQuickGO ontologyBLASTP
27272532727471219ATP synthase F0 C subunitQuickGO ontologyBLASTP
27275322728206675ATP synthase F0 A subunitQuickGO ontologyBLASTP
27282722728628357hypothetical proteinBLASTP
272931027304881179acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
273075627319101155UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
27319742732603630uracil phosphoribosyltransferaseQuickGO ontologyBLASTP