Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2524913 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
252491325269672055putative hydrolaseQuickGO ontologyBLASTP
252700425281401137putative stage IV sporulation proteinQuickGO ontologyBLASTP
25281422528438297sporulation protein YqfCQuickGO ontologyBLASTP
25286592529108450GatBYqey domain proteinQuickGO ontologyBLASTP
25291582529334177ribosomal protein S21QuickGO ontologyBLASTP
25294542529798345HIT family proteinQuickGO ontologyBLASTP
252986725311711305MiaB-like tRNA modifying enzymeQuickGO ontologyBLASTP
25311712531923753hypothetical proteinBLASTP
25319462532887942ribosomal protein L11 methyltransferaseQuickGO ontologyBLASTP
25331132533469357transcriptional regulator GntR familyQuickGO ontologyBLASTP
253347125346491179hypothetical protein
25346652535492828hypothetical protein
25354792536171693ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
253634725375101164chaperone protein DnaJQuickGO ontologyBLASTP
253762425394831860chaperone protein DnaKQuickGO ontologyBLASTP
25395402540166627co-chaperone GrpEQuickGO ontologyBLASTP
254019725412161020heat-inducible transcription repressor HrcAQuickGO ontologyBLASTP
254141325425461134putative oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP