Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:2481500 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24815312481908378lrgA family proteinQuickGO ontologyBLASTP
24819012482611711lrgB-like family proteinQuickGO ontologyBLASTP
24827092483164456hypothetical proteinBLASTP
248337724855392163DNA topoisomeraseQuickGO ontologyBLASTP
248576724869241158putative amidohydrolaseQuickGO ontologyBLASTP
24870872487584498TspOMBR family proteinQuickGO ontologyBLASTP
248763024896662037sensor histidine kinaseQuickGO ontologyBLASTP
248965624915181863sensor histidine kinaseQuickGO ontologyBLASTP
24916632492598936tetratricopeptide repeat proteinQuickGO ontologyBLASTP
24927192493639921hydrolase alphabeta fold familyQuickGO ontologyBLASTP
24937622494358597hypothetical proteinBLASTP
2494499249458486tRNA-LeuQuickGO ontologyBLASTP
249464424957591116glycosyl hydrolase family 8QuickGO ontologyBLASTP
24958112496356546transglycosylase SLT familyQuickGO ontologyBLASTP
24963662496965600dephospho-CoA kinaseQuickGO ontologyBLASTP
249698224995822601DNA polymerase IQuickGO ontologyBLASTP
24999392500856918glutaminaseQuickGO ontologyBLASTP
25010952501610516hypothetical proteinBLASTP
250169325029281236aminopeptidaseQuickGO ontologyBLASTP
250314125041901050hypothetical proteinBLASTP
250420725052171011hypothetical proteinBLASTP