Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:225425 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
225425226282858cobalt ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
226838227035198hypothetical proteinBLASTP
2272392281028645-nucleotidase lipoprotein eP4 familyQuickGO ontologyBLASTP
2283252295241200peptidase M23M37 familyQuickGO ontologyBLASTP
230210230866657hypothetical proteinBLASTP
231430232947151816S ribosomal RNAQuickGO ontologyBLASTP
233133236037290523S ribosomal RNAQuickGO ontologyBLASTP
2360902362071185S ribosomal RNAQuickGO ontologyBLASTP
23621923629476tRNA-PheQuickGO ontologyBLASTP
236809237438630hypothetical proteinBLASTP
237945238214270hypothetical proteinBLASTP
238273238425153hypothetical protein
239731240312582hypothetical proteinBLASTP
2404502428252376sensory box histidine kinaseQuickGO ontologyBLASTP
2431922442501059acyltransferase family proteinQuickGO ontologyBLASTP
244351244578228hypothetical proteinBLASTP
244718245599882hypothetical proteinBLASTP
2456092478252217hypothetical proteinBLASTP
248306249076771hypothetical proteinBLASTP
249255250070816mechanosensitive ion channel family proteinQuickGO ontologyBLASTP
250644251288645heme oxygenaseQuickGO ontologyBLASTP
2516892529121224putative nuclease SbcCD D subunitQuickGO ontologyBLASTP
2528992564173519exonuclease SbcCQuickGO ontologyBLASTP