Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:1787345 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
178734517898432499hypothetical protein
178985917917391881metallo-beta-lactamase family proteinQuickGO ontologyBLASTP
179179017948493060putative phage structural proteinQuickGO ontologyBLASTP
17948541795564711putative phage tail componentQuickGO ontologyBLASTP
179555717988113255phage tail tape measure protein TP901 familyQuickGO ontologyBLASTP
17988471799200354hypothetical protein
17993621799679318hypothetical proteinBLASTP
17996821800284603phage major tail protein phi13 familyQuickGO ontologyBLASTP
18003011800648348hypothetical proteinBLASTP
18006571801085429phage protein HK97 gp10 familyQuickGO ontologyBLASTP
18010941801423330putative phage head-tail adaptorQuickGO ontologyBLASTP
18014161801694279phage protein QlrG familyQuickGO ontology
180170618028901185phage major capsid protein HK97 familyQuickGO ontologyBLASTP
18029311803536606phage prohead protease HK97 familyQuickGO ontologyBLASTP
180352618047731248phage portal protein HK97 familyQuickGO ontologyBLASTP
180477418065131740putative phage terminase large subunitQuickGO ontologyBLASTP
18065061807018513putative phage terminase small subunitQuickGO ontologyBLASTP
18075211808342822hypothetical protein
18085171809065549site-specific recombinase phage integrase familyQuickGO ontologyBLASTP
18091601809513354hypothetical protein
18095721809778207hypothetical proteinBLASTP
18099201810381462putative DNA-binding proteinQuickGO ontologyBLASTP