Pre_GI Gene

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Host: NC_008261 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008261:1048515 Clostridium perfringens ATCC 13124, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10485151049165651pyrophosphatase MutTnudix familyQuickGO ontologyBLASTP
10492561049675420hypothetical proteinBLASTP
10500431050669627DedA family proteinQuickGO ontologyBLASTP
105093710520671131alcohol dehydrogenase iron-containingQuickGO ontologyBLASTP
10524211052771351ethanolamine utilization protein EutSQuickGO ontologyBLASTP
10527751053209435ethanolamine utilization protein EutPQuickGO ontologyBLASTP
10532271053802576response regulatorQuickGO ontologyBLASTP
105380610552331428sensor histidine kinaseQuickGO ontologyBLASTP
105544910568821434ethanolamine utilization protein EutAQuickGO ontologyBLASTP
105690110582681368ethanolamine ammonia-lyase large subunitQuickGO ontologyBLASTP
10582851059172888ethanolamine ammonia-lyase small subunitQuickGO ontologyBLASTP
10591941059847654ethanolamine utilization protein EutLQuickGO ontologyBLASTP
10598601060624765ethanolamine utilization proteinQuickGO ontologyBLASTP
106062410621021479ethanolamine utilization proteinQuickGO ontologyBLASTP
10624571062747291ethanolamine utilization protein EutMQuickGO ontologyBLASTP
10628251063601777ethanolamine utilization cobalamin adenosyltransferaseQuickGO ontologyBLASTP
10636111064246636ethanolamine utilization proteinQuickGO ontologyBLASTP
10644751065212738hypothetical proteinBLASTP
10653591065631273ethanolamine utilization protein EutNQuickGO ontologyBLASTP
10656331066187555ethanolamine utilization proteinQuickGO ontologyBLASTP
106623810673351098ethanolamine utilization protein EutHQuickGO ontologyBLASTP
10673381067811474ethanolamine utilization protein EutQQuickGO ontologyBLASTP
10681801068656477glutathione peroxidaseQuickGO ontologyBLASTP
10690881069633546acetyltransferase GNAT familyQuickGO ontologyBLASTP
10699251070236312hypothetical proteinBLASTP
10703251070456132hypothetical protein
107055010721901641EAL domain proteinQuickGO ontologyBLASTP
10722721072892621NADPH-dependent FMN reductaseQuickGO ontologyBLASTP