Pre_GI Gene

Some Help

Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:4345400 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43454004346302903FimH protein precursorQuickGO ontologyBLASTP
43463224346825504fimbrial morphologyQuickGO ontologyBLASTP
43468384347368531fimbrial morphologyQuickGO ontologyBLASTP
434737843500142637Outer membrane usher protein fimD precursorQuickGO ontologyBLASTP
43500814350737657Chaperone protein fimC precursorQuickGO ontologyBLASTP
43516534352156504IS1 ORF2QuickGO ontologyBLASTP
43522244352772549major type 1 subunit fimbrin pilinQuickGO ontologyBLASTP
43532534353807555Type 1 fimbriae Regulatory protein fimEQuickGO ontologyBLASTP
43544444354929486Type 1 fimbriae Regulatory protein fimBQuickGO ontologyBLASTP
43563834357099717hypothetical proteinBLASTP
435701143582251215hypothetical proteinBLASTP
43582904359270981hypothetical proteinBLASTP
43597394360242504IS1 ORF2QuickGO ontologyBLASTP
43603174360583267putative IS1 encoded proteinQuickGO ontologyBLASTP
43606214361226606putative deoR family transcriptional regulatorQuickGO ontologyBLASTP
43613274361443117hypothetical proteinBLASTP
43617024361980279ISEhe3 orfAQuickGO ontologyBLASTP
43620494362249201IS600 ORF1QuickGO ontologyBLASTP
43621174362419303putative IS1 encoded proteinQuickGO ontologyBLASTP
43624944362997504IS1 ORF2QuickGO ontologyBLASTP
436333843645311194putative P4-type integraseQuickGO ontologyBLASTP
4364730436481485tRNA-LeuQuickGO ontologyBLASTP
436501043660291020putative oxidoreductaseQuickGO ontologyBLASTP
436615843676601503hypothetical proteinBLASTP
436777943688611083hypothetical proteinBLASTP
436886143698981038hypothetical proteinBLASTP