Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:401786 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
40178640358217971-deoxyxylulose-5-phosphate synthaseQuickGO ontologyBLASTP
403673404572900geranyltranstransferase farnesyldiphosphate synthaseQuickGO ontologyBLASTP
404572404814243exonuclease VII small subunitQuickGO ontologyBLASTP
4050204064681449putative oxidoreductaseQuickGO ontologyBLASTP
4065224071125914-methyl-5beta-hydroxyethyl-thiazole monophosphate synthesisQuickGO ontologyBLASTP
407075407986912alternative pyrimidine biosynthesisQuickGO ontologyBLASTP
408154408645492hypothetical proteinBLASTP
4087054104351731hypothetical proteinBLASTP
4104884126412154hypothetical proteinBLASTP
4128234141931371putative transport proteinQuickGO ontologyBLASTP
4145874158611275putative periplasmic proteinQuickGO ontologyBLASTP
416098417033936hypothetical proteinBLASTP
417089417487399hypothetical proteinBLASTP
417622417981360hypothetical proteinBLASTP
419020419349330cytochrome o ubiquinol oxidase subunit IVQuickGO ontologyBLASTP
419349419963615cytochrome o ubiquinol oxidase subunit IIIQuickGO ontologyBLASTP
422496423302807ISSfl4 ORF3QuickGO ontologyBLASTP
423278423412135ISSfl4 ORF3QuickGO ontologyBLASTP
423432423779348ISSfl4 ORF2QuickGO ontologyBLASTP
423776424450675ISSfl4 ORF1QuickGO ontologyBLASTP
4248204262951476regulates beta-lactamase synthesisQuickGO ontologyBLASTP