Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:3995553 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39955533996182630DNA repair proteinQuickGO ontologyBLASTP
3996656399682316850S ribosomal subunit protein L33QuickGO ontologyBLASTP
39969213997730810formamidopyrimidine DNA glycosylaseQuickGO ontologyBLASTP
39977693998248480putative enzyme of lipopolysaccharide synthesisQuickGO ontologyBLASTP
3998256399953312783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
39995683999786219putative IS1 encoded proteinQuickGO ontologyBLASTP
39998614000364504IS1 ORF2QuickGO ontologyBLASTP
400075840017801023lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
400177740029011125LPS alpha13-glucosyltransferaseQuickGO ontologyBLASTP
40028944003691798lipopolysaccharide core biosynthesis proteinQuickGO ontologyBLASTP
400373440047411008Lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
40047674005474708putative LPS biosynthesis proteinQuickGO ontologyBLASTP
400549940065121014lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
400652140076631143lipopolysaccharide 12-N- acetylglucosaminetransferaseQuickGO ontologyBLASTP
400769940089071209lipid A-core surface polymer ligaseQuickGO ontologyBLASTP
40089044009896993lipopolysaccharide heptosyltransferase-1QuickGO ontologyBLASTP
400990040109461047ADP-heptose--lps heptosyltransferase IIQuickGO ontologyBLASTP
40109564011888933ADP-L-glycero-D-mannoheptose-6-epimeraseQuickGO ontologyBLASTP
40121774013049873HtrLQuickGO ontologyBLASTP
4013324401452011972-amino-3-ketobutyrate CoA ligaseQuickGO ontologyBLASTP
401453040155551026threonine dehydrogenaseQuickGO ontologyBLASTP
40157974016636840putative regulatorQuickGO ontologyBLASTP
40168814017384504IS1 ORF2QuickGO ontologyBLASTP
40175924018416825hypothetical proteinBLASTP
401855540198141260hypothetical proteinBLASTP
401984840214941647putative 23-bisphosphoglycerate-independent phosphoglycerate mutaseQuickGO ontologyBLASTP