Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:3581583 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35815833582476894hypothetical proteinBLASTP
358254835839001353glutathione oxidoreductaseQuickGO ontologyBLASTP
35847803585133354transcriptional repressor of chromosomal ars operonQuickGO ontologyBLASTP
358518735864761290arsenical pump membrane proteinQuickGO ontologyBLASTP
35864893586914426arsenate reductaseQuickGO ontologyBLASTP
35874133587664252putative IS1 encoded proteinQuickGO ontologyBLASTP
35877393588242504IS1 ORF2QuickGO ontologyBLASTP
35882673589229963hypothetical proteinBLASTP
358981035910331224hypothetical proteinBLASTP
35911153591846732outer membrane protein induced after carbon starvationQuickGO ontologyBLASTP
35920023592532531hypothetical proteinBLASTP
35932843593610327hypothetical proteinBLASTP
35937263594058333hypothetical proteinBLASTP
35943133594885573hypothetical proteinBLASTP
35956843596211528hypothetical proteinBLASTP
35976083598111504IS1 ORF2QuickGO ontologyBLASTP
35982253598854630IS150 ORF1ORF AQuickGO ontologyBLASTP
35988513599702852IS150 ORF2QuickGO ontologyBLASTP
36001433600355213Cold shock protein cspAQuickGO ontologyBLASTP
36006363600926291hypothetical proteinBLASTP
36012403602070831hypothetical proteinBLASTP
36021203603094975putative dehydrogenaseQuickGO ontologyBLASTP
36031983603848651putative outer membrane proteinQuickGO ontologyBLASTP
360406536063442280biotin sulfoxide reductaseQuickGO ontologyBLASTP
36063133606753441hypothetical proteinBLASTP
360675036074787293-methyl-adenine DNA glycosylase I constitutiveQuickGO ontologyBLASTP
36074713608169699putative lipaseQuickGO ontologyBLASTP