Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:3224721 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
322472132260851365putative L-serine dehydrataseQuickGO ontologyBLASTP
32261573226609453hypothetical proteinBLASTP
322656032288542295probable formate acetyltransferase 3QuickGO ontologyBLASTP
322888832300961209putative kinaseQuickGO ontologyBLASTP
323012232314531332anaerobically inducible L-threonine L-serine permeaseQuickGO ontologyBLASTP
32314753232464990threonine dehydratase catabolicQuickGO ontologyBLASTP
32325633233501939transcriptional activator of tdc operonQuickGO ontologyBLASTP
32336913234035345threonine dehydratase operon activator proteinQuickGO ontologyBLASTP
32342913234830540hypothetical proteinBLASTP
32348523235568717hypothetical proteinBLASTP
32366413237030390hypothetical proteinBLASTP
323704932382751227hypothetical proteinBLASTP
32382913239175885putative dehydrogenaseQuickGO ontologyBLASTP
32392113239756546hypothetical proteinBLASTP
323999732412831287putative transport proteinQuickGO ontologyBLASTP
32412853241788504IS1 ORF2QuickGO ontologyBLASTP
32418633242042180putative IS1 encoded proteinQuickGO ontologyBLASTP
32426183243313696putative chaperoneQuickGO ontologyBLASTP
32450783245917840IS2 ORF2QuickGO ontologyBLASTP
32459413246306366IS2 ORF1QuickGO ontologyBLASTP