Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:269806 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2684812698091329tailDNA circulation proteinQuickGO ontologyBLASTP
2698062708851080tail proteinQuickGO ontologyBLASTP
270885271433549tail proteinQuickGO ontologyBLASTP
271433271858426tail proteinQuickGO ontologyBLASTP
2718452729031059hypothetical proteinBLASTP
272894273478585hypothetical proteinBLASTP
274041274544504hypothetical proteinBLASTP
2746672759201254serotype-specific glucosyl transferaseQuickGO ontologyBLASTP
275917276840924bactoprenol glucosyl transferaseQuickGO ontologyBLASTP
276837277199363bactoprenol-linked glucose translocaseQuickGO ontologyBLASTP
2774612786211161putative integraseQuickGO ontologyBLASTP
279662280501840putative bacteriophage proteinQuickGO ontologyBLASTP
280503281159657putative bacteriophage proteinQuickGO ontologyBLASTP
281146281463318hypothetical protein
281566281922357putative bacteriophage proteinQuickGO ontologyBLASTP
282426282908483hypothetical proteinBLASTP
282892283794903putative phage-related DNA recombination proteinQuickGO ontologyBLASTP
283791284099309hypothetical proteinBLASTP
284251284493243putative IS1 encoded proteinQuickGO ontologyBLASTP
284568285071504IS1 ORF2QuickGO ontologyBLASTP
286308286631324putative bacteriophage proteinQuickGO ontologyBLASTP
287337287969633putative prophage repressor CIQuickGO ontologyBLASTP
2883692897151347IS4 ORFQuickGO ontologyBLASTP
290308291132825replication protein OQuickGO ontologyBLASTP
2911222925581437replication protein PQuickGO ontologyBLASTP
293591293821231hypothetical proteinBLASTP
293814294536723putative DNA-binding protein Roi of bacteriophage BP-933WQuickGO ontologyBLASTP
294823295185363putative crossover junction endodeoxyribonucleaseQuickGO ontologyBLASTP