Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2542863 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
25428632543762900coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
254376825448201053putative ARAC-type regulatory proteinQuickGO ontologyBLASTP
25448662545366501hypothetical proteinBLASTP
25453792546038660hypothetical proteinBLASTP
25472202547963744hypothetical proteinBLASTP
25481912548673483IS1 ORF2QuickGO ontologyBLASTP
25495072549761255hypothetical proteinBLASTP
25499192550182264hypothetical proteinBLASTP
25502052550747543hypothetical proteinBLASTP
25512122551418207hypothetical proteinBLASTP
25517302552215486hypothetical proteinBLASTP
255246725539271461putative amino acid antiporterQuickGO ontologyBLASTP
25540782554770693hypothetical proteinBLASTP
25548892555284396iso-IS1 ORF2QuickGO ontologyBLASTP
25556182556457840IS2 ORF2QuickGO ontologyBLASTP
25564812556846366IS2 ORF1QuickGO ontologyBLASTP
255743925588121374hypothetical proteinBLASTP
25587872559266480hypothetical proteinBLASTP
25592792559686408hypothetical proteinBLASTP
255990725621862280putative multimodular enzymeQuickGO ontologyBLASTP
25624752563425951transaldolase AQuickGO ontologyBLASTP
256344525654482004transketolase 2 isozymeQuickGO ontologyBLASTP