Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2473000 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
247310124745341434sucrose hydrolaseQuickGO ontologyBLASTP
24745422475495954sucrose operon repressorQuickGO ontologyBLASTP
24757682475986219D-serine permeaseQuickGO ontologyBLASTP
247600424773321329D-serine dehydrataseQuickGO ontologyBLASTP
247744024789781539multidrug resistance protein YQuickGO ontologyBLASTP
247897824801411164multidrug resistance protein KQuickGO ontologyBLASTP
24805582481172615putative positive transcription regulatorQuickGO ontologyBLASTP
248117724847703594putative sensor for regulator EvgAQuickGO ontologyBLASTP
248482624860101185putative enzymeQuickGO ontologyBLASTP
24860452486989945putative receptor proteinQuickGO ontologyBLASTP
248705924887531695putative enzymeQuickGO ontologyBLASTP
248880724900571251putative enzymeQuickGO ontologyBLASTP
24905702491193624hypothetical proteinBLASTP
24918422492084243hypothetical proteinBLASTP
24924372493357921putative heat shock proteinQuickGO ontologyBLASTP
249384824950021155putative aminotransferaseQuickGO ontologyBLASTP
249582824969491122putative sensor proteinQuickGO ontologyBLASTP
24969642497698735putative 2-component transcriptional regulatorQuickGO ontologyBLASTP