Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:2100646 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
209934521006491305histidinol dehydrogenaseQuickGO ontologyBLASTP
210064621017161071histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
210171621027831068imidazole glycerol-phosphate dehydratasehistidinol phosphataseQuickGO ontologyBLASTP
21027832103373591imidazole glycerol phosphate synthase subunit HisHQuickGO ontologyBLASTP
21033732104110738N-5-phospho-L-ribosyl-formimino-5-amino-1- 5- phosphoribosyl-4-imidazolecarboxamide isomeraseQuickGO ontologyBLASTP
21040922104868777imidazole glycerol phsphate synthase holoenzymeQuickGO ontologyBLASTP
21048622105473612phosphoribosyl-amp cyclohydrolase phosphoribosyl-ATP pyrophosphataseQuickGO ontologyBLASTP
210565921066721014regulator of length of O-antigen component of lipopolysaccharide chainsQuickGO ontologyBLASTP
210815221095581407gluconate-6-phosphate dehydrogenaseQuickGO ontologyBLASTP
21106752111325651hypothetical proteinBLASTP
211282521139731149O-antigen polymeraseQuickGO ontologyBLASTP
21139932114898906dTDP-rhamnosyl transferaseQuickGO ontologyBLASTP
21148912115652762dTDP-rhamnosyl transferaseQuickGO ontologyBLASTP
211581121170671257polysaccharide biosynthesis proteinQuickGO ontologyBLASTP
21170832117628546dTDP-4-dehydrorhamnose 35-epimeraseQuickGO ontologyBLASTP
21176332118511879glucose-1-phosphate thymidylyltransferaseQuickGO ontologyBLASTP
21185702119469900dTDP-6-deoxy-L-mannose-dehydrogenaseQuickGO ontologyBLASTP
211946921205541086dTDP-glucose 46 dehydrataseQuickGO ontologyBLASTP
21209272121820894UTP--glucose-1-P uridyltransferaseQuickGO ontologyBLASTP
212340021246201221putative colanic acid biosynthesis glycosyl transferaseQuickGO ontologyBLASTP
212461721258971281putative galactokinaseQuickGO ontologyBLASTP
212607721275551479probable export proteinQuickGO ontologyBLASTP
212755721289511395putative colanic acid biosynthsis UDP-glucose lipid carrier transferaseQuickGO ontologyBLASTP
213057021318891320mannose-1-phosphate guanyltransferaseQuickGO ontologyBLASTP