Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:1873805 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
18738051874557753Fumarate and nitrate reduction Regulatory proteinQuickGO ontologyBLASTP
18747091875659951hypothetical proteinBLASTP
18757991875966168hypothetical proteinBLASTP
18761661876732567IS911 ORF2QuickGO ontologyBLASTP
18770331877335303IS911 ORF1QuickGO ontologyBLASTP
187746318784941032hypothetical proteinBLASTP
187854518801791635putative transport periplasmic proteinQuickGO ontologyBLASTP
18810261881328303IS600 ORF1QuickGO ontologyBLASTP
18814691882182714IS600 ORF2QuickGO ontologyBLASTP
18831301883402273putative host-nuclease inhibitor protein GamQuickGO ontologyBLASTP
188348618845291044putative bacteriophage proteinQuickGO ontologyBLASTP
18848691885171303IS600 ORF1QuickGO ontologyBLASTP
18853121886025714IS600 ORF2QuickGO ontologyBLASTP
188638918874651077putative phage integrase proteinQuickGO ontologyBLASTP
18878581888199342hypothetical proteinBLASTP
18882121889084873putative resistance proteinQuickGO ontologyBLASTP
18890881889462375hypothetical proteinBLASTP
18896011889831231DNA polymerase III theta subunitQuickGO ontologyBLASTP
18901641890589426hypothetical proteinBLASTP
18906131891275663hypothetical proteinBLASTP
189127218933322061protease IIQuickGO ontologyBLASTP
18935411894200660hypothetical proteinBLASTP
18945271894895369hypothetical proteinBLASTP
189537418965521179phosphoribosylglycinamide formyltransferase 2QuickGO ontologyBLASTP