Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:1784637 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17846371785290654formate dehydrogenase-N nitrate-inducible cytochrome B556Fdn gamma subunitQuickGO ontologyBLASTP
17852831786167885formate dehydrogenase-N nitrate-inducible iron-sulfur beta subunitQuickGO ontologyBLASTP
178618017892273048formate dehydrogenase-N nitrate-inducible alpha subunitQuickGO ontologyBLASTP
17895161790340825hypothetical proteinBLASTP
17905431791046504IS1 ORF2QuickGO ontologyBLASTP
17911211791309189putative IS1 encoded proteinQuickGO ontologyBLASTP
179137217924721101putative outer membrane porin proteinQuickGO ontologyBLASTP
17926421793121480hypothetical proteinBLASTP
17932311794220990putative glycoporteinQuickGO ontologyBLASTP
17943941794627234putative IS1 encoded proteinQuickGO ontologyBLASTP
17947021795205504IS1 ORF2QuickGO ontologyBLASTP
179566317970511389nitrite extrusion protein 2QuickGO ontologyBLASTP
179713318008733741cryptic nitrate reductase 2 alpha subunitQuickGO ontologyBLASTP
18008701801802933putative cryptic nitrate reductase 2 beta subunitQuickGO ontologyBLASTP
18018371802202366putative IS91 ORF2QuickGO ontologyBLASTP
180231618033891074IS91 ORFQuickGO ontologyBLASTP
18036601804325666hypothetical proteinBLASTP
180448718055901104putative oxidoreductaseQuickGO ontologyBLASTP