Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:1750964 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17520341752537504IS1 ORF2QuickGO ontologyBLASTP
175324917544091161putative amino acidamine transport proteinQuickGO ontologyBLASTP
17545301754709180putative IS1 encoded proteinQuickGO ontologyBLASTP
17547841755287504IS1 ORF2QuickGO ontologyBLASTP
17553141756063750putative oxidoreductaseQuickGO ontologyBLASTP
175609417568527593-dehydroquinate dehydrataseQuickGO ontologyBLASTP
17569341757437504IS1 ORF2QuickGO ontologyBLASTP
17575121757739228putative IS1 encoded proteinQuickGO ontologyBLASTP
175774217592321491putative sulfataseQuickGO ontologyBLASTP
175928417604411158putative enzymeQuickGO ontologyBLASTP
17619311762167237putative IS1 encoded proteinQuickGO ontologyBLASTP
17622421762745504IS1 ORF2QuickGO ontologyBLASTP
176323217655922361hypothetical proteinBLASTP
17668951767398504IS1 ORF2QuickGO ontologyBLASTP
176957017709701401glutamate decarboxylase isozymeQuickGO ontologyBLASTP
177112617726611536acid sensitivity protein putative transporterQuickGO ontologyBLASTP
177279217741111320hypothetical proteinBLASTP