Pre_GI Gene

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Host: NC_008258 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008258:1076922 Shigella flexneri 5 str. 8401, complete genome

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
10780351078448414hypothetical proteinBLASTP
107845010797751326hypothetical proteinBLASTP
10810271081530504IS1 ORF2QuickGO ontologyBLASTP
10865941086932339hypothetical proteinBLASTP
108703010884811452Rtn-like proteinQuickGO ontologyBLASTP
10888921089758867IS3 ORF2QuickGO ontologyBLASTP
10897551090054300IS3 ORF1QuickGO ontologyBLASTP
10901571090537381hypothetical proteinBLASTP
10906461091632987hypothetical proteinBLASTP
1091825109191288tRNA-SerQuickGO ontologyBLASTP
10931401093877738hypothetical proteinBLASTP
10939011094455555putative oxidoreductase componentQuickGO ontologyBLASTP
10945091095048540hypothetical proteinBLASTP
10959141096330417curli production assemblytransport component csgF precursorQuickGO ontologyBLASTP
10963551096744390Curli production assemblytransport component csgE precursorQuickGO ontologyBLASTP
10967491097399651Probable csgAB operon transcriptional Regulatory proteinQuickGO ontologyBLASTP
10981531098608456minor curlin subunit precursorQuickGO ontologyBLASTP
10988221099124303IS600 ORF1QuickGO ontologyBLASTP
10992651099903639IS600 ORF2QuickGO ontologyBLASTP