Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:905000 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9051429069051764ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
907133907786654hypothetical proteinBLASTP
9078309090381209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
909174909944771molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
9099469112201275molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
9117559130651311putative heme-binding proteinQuickGO ontologyBLASTP
913075913743669ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
9137459150071263hypothetical proteinBLASTP
9150099173692361hypothetical proteinBLASTP
917922918764843putative esteraseQuickGO ontologyBLASTP
9187859199241140alcohol dehydrogenaseQuickGO ontologyBLASTP
920198921067870putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
9212039223541152hypothetical proteinBLASTP
922496923200705GTP cyclohydrolase IQuickGO ontologyBLASTP
9232559244211167hypothetical proteinBLASTP
925169926161993galactose-binding proteinQuickGO ontologyBLASTP
9263919279111521galactoside transport ATP-binding proteinQuickGO ontologyBLASTP
9279329289421011galactoside permeaseQuickGO ontologyBLASTP