Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:844727 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8447278467812055putative helicase IVQuickGO ontologyBLASTP
846842847306465methylglyoxal synthaseQuickGO ontologyBLASTP
847485848165681hypothetical proteinBLASTP
848481848897417hypothetical proteinBLASTP
849006849323318hypothetical proteinBLASTP
8493848505741191hypothetical proteinBLASTP
850668850946279putative acylphosphataseQuickGO ontologyBLASTP
850998851327330putative sulfite reductase subunit proteinQuickGO ontologyBLASTP
852075852362288putative transposaseQuickGO ontologyBLASTP
852726853088363hypothetical proteinBLASTP
853095853373279hypothetical proteinBLASTP
853559854539981hypothetical proteinBLASTP
8549738573902418putative oxidoreductaseQuickGO ontologyBLASTP
857544858290747putative short chain dehydrogenaseQuickGO ontologyBLASTP
858919859239321hypothetical proteinBLASTP
859503860027525putative 3R-hydroxymyristoyl-acyl-carrier-protein dehydraseQuickGO ontologyBLASTP
8600178613001284putative beta-ketoacyl-acyl-carrier-protein synthaseQuickGO ontologyBLASTP
861293862039747putative beta-ketoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
8620558632931239putative hydroxymethylglutaryl-coenzyme A synthaseQuickGO ontologyBLASTP
863286864005720putative enoyl-CoA hydrataseQuickGO ontologyBLASTP
863983864759777putative enoyl-CoA hydrataseQuickGO ontologyBLASTP
864762865550789putative short chain dehydrogenaseQuickGO ontologyBLASTP
865616866077462hypothetical proteinBLASTP
866115866363249putative acyl carrier proteinQuickGO ontologyBLASTP
866462867310849putative acyl transferaseQuickGO ontologyBLASTP
8680228690441023transposase for insertion sequence IS100QuickGO ontologyBLASTP
869044869823780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
870258870758501hypothetical proteinBLASTP
8708078723511545hypothetical proteinBLASTP
8723638737151353hypothetical proteinBLASTP
873712874398687hypothetical proteinBLASTP
8743988761341737hypothetical proteinBLASTP
876138876629492hypothetical proteinBLASTP
8770178796592643putative ATPase subunit of ATP-dependent proteaseQuickGO ontologyBLASTP
8796628820102349hypothetical proteinBLASTP
8820958843262232hypothetical proteinBLASTP
884323885096774hypothetical proteinBLASTP
885250885510261hypothetical proteinBLASTP
8855268877092184hypothetical proteinBLASTP
887882888352471hypothetical proteinBLASTP
888817888954138putative transposaseQuickGO ontologyBLASTP
889085889405321putative transposaseQuickGO ontologyBLASTP
889514889687174IS630 ORFQuickGO ontologyBLASTP