Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:650899 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
650899651075177hypothetical proteinBLASTP
651490651807318putative prophage proteinQuickGO ontologyBLASTP
651813652127315putative DNA-binding prophage proteinQuickGO ontologyBLASTP
6524766535641089putative regulatory prophage proteinQuickGO ontologyBLASTP
653561654520960putative prophage DNA primaseQuickGO ontologyBLASTP
654513655055543putative prophage proteinQuickGO ontologyBLASTP
655055655255201transcriptional regulatorQuickGO ontologyBLASTP
655248656135888putative DNA-binding prophage proteinQuickGO ontologyBLASTP
656157656480324hypothetical proteinBLASTP
656943657170228hypothetical proteinBLASTP
6573326590021671hypothetical proteinBLASTP
6590536601411089hypothetical proteinBLASTP
6602206614191200putative prophage integraseQuickGO ontologyBLASTP
661643662101459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
662736663230495SsrA-binding protein small protein BQuickGO ontologyBLASTP
663379663813435hypothetical proteinBLASTP
663806664090285hypothetical proteinBLASTP
664240664581342hypothetical proteinBLASTP
6646956663561662DNA repair protein RecNQuickGO ontologyBLASTP
666443667324882hypothetical proteinBLASTP
667448668026579heat shock protein GrpEQuickGO ontologyBLASTP
6681346694141281citrate synthase GltAQuickGO ontologyBLASTP
670124670513390succinate dehydrogenase cytochrome b-556 subunitQuickGO ontologyBLASTP
670507670854348succinate dehydrogenase hydrophobic membrane anchor proteinQuickGO ontologyBLASTP
6708556726211767succinate dehydrogenase flavoprotein subunitQuickGO ontologyBLASTP
672671673387717succinate dehydrogenase iron-sulfur proteinQuickGO ontologyBLASTP