Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:4634695 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
46337464634705960putative iron transport permeaseQuickGO ontologyBLASTP
463469546357021008putative iron transport permeaseQuickGO ontologyBLASTP
46356994636457759putative iron ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
46364544637017564hypothetical proteinBLASTP
46371904637375186hypothetical proteinBLASTP
46384594638821363putative regulatorQuickGO ontologyBLASTP
46389934639499507putative transposaseQuickGO ontologyBLASTP
46395354639792258hypothetical proteinBLASTP
464047946419511473hypothetical proteinBLASTP
464184546430381194putative phage integraseQuickGO ontologyBLASTP
4643204464329491tRNA-SecQuickGO ontologyBLASTP
464342446446171194putative AraC-family transcriptional regulatory proteinQuickGO ontologyBLASTP
464470746458911185sugar transport system permease proteinQuickGO ontologyBLASTP
464587846474101533sugar transport ATP-binding proteinQuickGO ontologyBLASTP
46476184648613996sugar-binding periplasmic proteinQuickGO ontologyBLASTP
464907646503951320xylose isomeraseQuickGO ontologyBLASTP
465051946519731455xylulose kinaseQuickGO ontologyBLASTP
46520914653077987hypothetical proteinBLASTP
46531164653883768putative fimbrial chaperoneQuickGO ontologyBLASTP
46539764654209234outer membrane fimbrial usher porinQuickGO ontologyBLASTP
46542104654611402outer membrane fimbrial usher porinQuickGO ontologyBLASTP
465463746564661830hypothetical proteinBLASTP