Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:4601202 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
46012024602020819dimethyladenosine transferaseQuickGO ontologyBLASTP
460201346030171005pyridoxal phosphate biosynthetic proteinQuickGO ontologyBLASTP
460299246042961305survival protein SurA precursor peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
460436446067422379organic solvent tolerance protein precursorQuickGO ontologyBLASTP
46068914607724834DnaJ-like proteinQuickGO ontologyBLASTP
46080224608642621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
46086864608811126hypothetical proteinBLASTP
46098654610527663hypothetical proteinBLASTP
46109534611951999hypothetical proteinBLASTP
46119624612522561hypothetical proteinBLASTP
46125224613187666hypothetical proteinBLASTP
46132314614010780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
461401046150321023transposase for insertion sequence IS100QuickGO ontologyBLASTP
46151144615914801hypothetical proteinBLASTP
46159114616501591two-component system response regulatorQuickGO ontologyBLASTP
461661746183081692hypothetical proteinBLASTP
461883746203001464hypothetical proteinBLASTP