Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:4561633 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
456163345640922460bifunctional aspartokinasehomoserine dehydrogenase IQuickGO ontologyBLASTP
45640954565024930homoserine kinaseQuickGO ontologyBLASTP
456502845663171290threonine synthaseQuickGO ontologyBLASTP
45671344567913780hypothetical proteinBLASTP
4568193456828593hypothetical proteinBLASTP
45684264569394969transaldolase BQuickGO ontologyBLASTP
45694384569596159hypothetical proteinBLASTP
45696824570269588molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
457039745717851389putative transport proteinQuickGO ontologyBLASTP
457185545743022448hypothetical proteinBLASTP
45745914575202612hypothetical proteinBLASTP
457557645774861911chaperone protein DnaKQuickGO ontologyBLASTP
457759845787371140chaperone protein DnaJQuickGO ontologyBLASTP
457898045801641185sodium-proton antiporterQuickGO ontologyBLASTP
45802944581193900transcriptional activator protein NhaRQuickGO ontologyBLASTP
4581324458158726430S ribosomal protein S20QuickGO ontologyBLASTP