Pre_GI Gene

Some Help

Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:4373722 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43737224374258537hypothetical proteinBLASTP
437496443761601197hypothetical proteinBLASTP
437617143772171047M48 peptidase family proteinQuickGO ontologyBLASTP
437736343785171155hypothetical proteinBLASTP
437851443799261413hypothetical proteinBLASTP
43805434380830288hypothetical proteinBLASTP
438117443825471374hypothetical proteinBLASTP
43825194383241723hypothetical proteinBLASTP
438329143846161326modification methylaseQuickGO ontologyBLASTP
43846294385096468hypothetical proteinBLASTP
43853434385573231hypothetical proteinBLASTP
438564043869561317hypothetical proteinBLASTP
438695343890162064hypothetical proteinBLASTP
438915043901721023transposase for insertion sequence IS100QuickGO ontologyBLASTP
43901724390951780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
43910024391106105hypothetical proteinBLASTP
43912914391602312putative lipoproteinQuickGO ontologyBLASTP
439167443933171644putative acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
43937254394465741putative methylaseQuickGO ontologyBLASTP
439458443971182535ribonuclease RQuickGO ontologyBLASTP