Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:4140804 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
414080441452944491insecticidal toxin complexQuickGO ontologyBLASTP
414535141489443594putative toxin subunitQuickGO ontologyBLASTP
414898541502081224putative insecticial toxinQuickGO ontologyBLASTP
415017741514751299putative insecticial toxinQuickGO ontologyBLASTP
41517114152577867putative lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
41528384153749912lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
41540524154255204hypothetical proteinBLASTP
41542634155198936putative HlyD family secretion proteinQuickGO ontologyBLASTP
415520041571551956hypothetical proteinBLASTP
415742241585551134hypothetical proteinBLASTP
41585524158890339succinate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
41590854159558474putative ribonucleaseQuickGO ontologyBLASTP
41595634159844282putative ribonuclease inhibitorQuickGO ontologyBLASTP
41599564160504549hypothetical proteinBLASTP