Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:3711953 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3711953372307011118putative autotransporter proteinQuickGO ontologyBLASTP
372317337250531881putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
37256163726491876putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
37268213727279459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
372741137292281818putative antigenic leucine-rich repeat proteinQuickGO ontologyBLASTP
37292473729432186hypothetical protein
372994737315031557putative integral membrane efflux proteinQuickGO ontologyBLASTP
373158137328131233peptidaseQuickGO ontologyBLASTP
373320137352732073putative TonB-dependent outer membrane receptorQuickGO ontologyBLASTP
373542437388373414hypothetical proteinBLASTP
373885137398731023transposase for insertion sequence IS100QuickGO ontologyBLASTP
37398733740652780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
374066837473186651putative siderophore biosysnthesis proteinQuickGO ontologyBLASTP