Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:361224 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3612243633682145putative hydroxamate-type ferrisiderophore receptorQuickGO ontologyBLASTP
3633613644611101hypothetical proteinBLASTP
3647433658311089membrane-bound lytic murein transglycosylase CQuickGO ontologyBLASTP
366002366274273hypothetical proteinBLASTP
3664523675701119AG-specific adenine glycosylaseQuickGO ontologyBLASTP
367905368624720Putative methyltransferaseQuickGO ontologyBLASTP
368624368950327hypothetical proteinBLASTP
369061369987927putative glutaminaseQuickGO ontologyBLASTP
370099370629531hypothetical proteinBLASTP
370587370832246hypothetical proteinBLASTP
3713313806639333putative virulence determinantQuickGO ontologyBLASTP
3808533819951143putative oxygen-independent coproporphyrinogen III oxidaseQuickGO ontologyBLASTP
381976382569594hypothetical proteinBLASTP
382669382959291hypothetical proteinBLASTP
382956383510555hypothetical proteinBLASTP
383798384619822putative pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
384752385450699hypothetical proteinBLASTP
3854703865941125hypothetical proteinBLASTP
3867033878181116hypothetical proteinBLASTP
387822388706885putative carbon-nitrogen hydrolaseQuickGO ontologyBLASTP
388886389308423hypothetical proteinBLASTP
389308389871564hypothetical proteinBLASTP
389987390946960glutathione synthetaseQuickGO ontologyBLASTP