Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:3495851 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34958513496321471hypothetical proteinBLASTP
349633034977121383hypothetical proteinBLASTP
34983353499114780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
349911435001361023transposase for insertion sequence IS100QuickGO ontologyBLASTP
35005903500748159hypothetical proteinBLASTP
35007453501119375hypothetical proteinBLASTP
35010533501256204hypothetical proteinBLASTP
35017073502639933LysR-family regulatory proteinQuickGO ontologyBLASTP
35028013503517717hypothetical proteinBLASTP
35037773504079303hypothetical proteinBLASTP
35042943504698405putative translational inhibitor proteinQuickGO ontologyBLASTP
35049833505363381putative translational inhibitor proteinQuickGO ontologyBLASTP
35053793506005627hypothetical proteinBLASTP
35060053506142138hypothetical proteinBLASTP
35061393506585447hypothetical proteinBLASTP
350658935080401452hypothetical proteinBLASTP
350803335092651233putative aminotransferaseQuickGO ontologyBLASTP
35100313510231201hypothetical proteinBLASTP
35102283510563336hypothetical proteinBLASTP
351057335116221050putative HlyD family secretion proteinQuickGO ontologyBLASTP
351160635135071902hypothetical proteinBLASTP
351351235150381527hypothetical proteinBLASTP
351510235172852184putative glycosyl hydrolaseQuickGO ontologyBLASTP
35173363517851516hypothetical proteinBLASTP
35178483518666819putative permeaseQuickGO ontologyBLASTP
35186663519547882putative permease proteinQuickGO ontologyBLASTP