Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:3430000 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
343005534311341080periplasmic binding proteinQuickGO ontologyBLASTP
343134634324521107Fimbrial proteinQuickGO ontologyBLASTP
34324773433196720fimbrial chaperone proteinQuickGO ontologyBLASTP
343321434356942481outer membrane usher proteinQuickGO ontologyBLASTP
34360473436505459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
34367053437127423hypothetical proteinBLASTP
34371793438045867hypothetical proteinBLASTP
34380423438896855hypothetical proteinBLASTP
34389113439360450putative outer membrane secretin family proteinQuickGO ontologyBLASTP
343965834407851128hypothetical proteinBLASTP
344079734420831287putative type II secretion proteinQuickGO ontologyBLASTP
34420803442955876hypothetical proteinBLASTP
34429523443785834hypothetical proteinBLASTP
34437693444539771hypothetical proteinBLASTP
34445363445009474hypothetical proteinBLASTP
34449933445565573hypothetical proteinBLASTP
344559034471461557hypothetical proteinBLASTP
34472433447668426ExbDTolR-family transport proteinQuickGO ontologyBLASTP
344767834487151038MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
344919434504051212putative cystathionine beta-lyaseQuickGO ontologyBLASTP
34505983451149552putative DedA-family membrane proteinQuickGO ontologyBLASTP
34513593452252894AraC-family regulatory proteinQuickGO ontologyBLASTP
345265034538071158putative iron-containing alcohol dehydrogenaseQuickGO ontologyBLASTP
34542263455059834putative aldoketo reductase family proteinQuickGO ontologyBLASTP