Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:317903 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3161583179061749putative siderophore biosynthesis protein IucCQuickGO ontologyBLASTP
317903318853951putative siderophore biosynthesis protein IucBQuickGO ontologyBLASTP
3188373199071071siderophore biosynthesis protein IucA famillyQuickGO ontologyBLASTP
320000320608609hypothetical proteinBLASTP
3207483219711224hypothetical proteinBLASTP
322261323094834hypothetical proteinBLASTP
3234713248471377hypothetical proteinBLASTP
325409326152744quorum-sensing transcriptional regulatorQuickGO ontologyBLASTP
326133326783651N-acylhomoserine lactone synthase YspIQuickGO ontologyBLASTP
327958328608651hypothetical proteinBLASTP
329059329454396putative lipoproteinQuickGO ontologyBLASTP
329522329785264insertion element proteinQuickGO ontologyBLASTP
331730332230501hypothetical proteinBLASTP
3322793338171539hypothetical proteinBLASTP
3338293351811353hypothetical proteinBLASTP
335178335864687hypothetical proteinBLASTP
3358643376001737putative OmpA-family membrane proteinQuickGO ontologyBLASTP
337604338095492hypothetical proteinBLASTP
3385133411612649Clp ATPaseQuickGO ontologyBLASTP
3411583435062349hypothetical proteinBLASTP
3435903457432154hypothetical proteinBLASTP
346640346915276insertion sequence proteinQuickGO ontologyBLASTP
346971347228258putative transposaseQuickGO ontologyBLASTP
347836348471636hypothetical proteinBLASTP
3484873507842298putative kinaseQuickGO ontologyBLASTP
350771351538768hypothetical proteinBLASTP