Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:3015000 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
30151463015895750hypothetical proteinBLASTP
301623230174911260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
301750130186041104glutamate 5-kinaseQuickGO ontologyBLASTP
30187813019182402curlin genes regulatory proteinQuickGO ontologyBLASTP
301924230204891248hypothetical proteinBLASTP
30206163021074459xanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
302200330236071605putative carbohydrate-binding proteinQuickGO ontologyBLASTP
30240673024978912putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
302685330283131461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
302842730294851059DNA-damage-inducible protein PQuickGO ontologyBLASTP
30298413030788948hypothetical proteinBLASTP
30310323031259228hypothetical proteinBLASTP
303127230323511080thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
303233530335581224NADH-uniquinone oxidoreductase subunit FQuickGO ontologyBLASTP
30335743034170597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
30341773034806630Na-translocating NADH-quinone reductase subunit DQuickGO ontologyBLASTP
30347993035599801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
303558930368301242NADH-ubiquinone oxidoreductase subunit BQuickGO ontologyBLASTP
303683430382161383NADH-ubiquinone oxidoreductase subunit AQuickGO ontologyBLASTP
30382793038458180hypothetical proteinBLASTP