Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2878450 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28784502878689240hypothetical proteinBLASTP
28787932879416624hypothetical proteinBLASTP
287941028803789695-nucleotidase2 3-cyclic phosphodiesteraseQuickGO ontologyBLASTP
28801912880448258protein UshA precursor UDP-sugar hydrolase UDP-sugar diphosphatase UDP-sugar pyrophosphatase 5-nucleotidase 5-NTQuickGO ontologyBLASTP
288073028819441215putative membrane efflux proteinQuickGO ontologyBLASTP
288217928838701692putative potassium antiporterQuickGO ontologyBLASTP
288396728852711305inosine-guanosine kinaseQuickGO ontologyBLASTP
288547528866261152O-antigen chain length determinantQuickGO ontologyBLASTP
288667428880471374phosphomannomutaseQuickGO ontologyBLASTP
28880522888795744glycosyltransferaseQuickGO ontologyBLASTP
288879828902041407mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
28904052891370966GDP-fucose synthetaseQuickGO ontologyBLASTP
28913762892062687GDP-mannose 46-dehydrataseQuickGO ontologyBLASTP
28919802892498519hypothetical proteinBLASTP
289251428935271014putative mannosyltransferaseQuickGO ontologyBLASTP
28937762894708933O-unit polymerase-like proteinQuickGO ontologyBLASTP
289499428961361143putative mannosyltransferaseQuickGO ontologyBLASTP
289724028984781239putative O-unit flippaseQuickGO ontologyBLASTP
289865728999401284hypothetical proteinBLASTP
28999412900798858paratose synthaseQuickGO ontologyBLASTP
290083529021481314putative CDP-4-keto-6-deoxy-D-glucose-3-dehydrataseQuickGO ontologyBLASTP
29021662903104939CDP-glucose 46-dehydrataseQuickGO ontologyBLASTP
29030972903240144hypothetical proteinBLASTP
29032452904030786glucose-1-phosphate cytidylyltransferaseQuickGO ontologyBLASTP
29040562905045990cdp-6-deoxy-delta-34-glucoseen reductaseQuickGO ontologyBLASTP
29056432906605963ferrochelataseQuickGO ontologyBLASTP
29066952907339645adenylate kinaseQuickGO ontologyBLASTP
290756629094401875heat shock protein HtpGQuickGO ontologyBLASTP
29094592909617159hypothetical proteinBLASTP
29096322910237606recombination protein RecRQuickGO ontologyBLASTP
29102372910569333hypothetical proteinBLASTP
291062529126011977DNA polymerase III subunit Tau contains DNA polymerase III subunit GammaQuickGO ontologyBLASTP
29132572913820564adenine phosphoribosyltransferaseQuickGO ontologyBLASTP
29140592914439381hypothetical proteinBLASTP