Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2822689 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
28226892823567879hypothetical proteinBLASTP
282360128248091209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
282496628263751410hypothetical proteinBLASTP
28265882826833246putative DNA-binding proteinQuickGO ontologyBLASTP
28275062828087582hypothetical proteinBLASTP
28281592828362204hypothetical proteinBLASTP
28283552828756402hypothetical proteinBLASTP
28290102829390381hypothetical proteinBLASTP
28294022829974573hypothetical proteinBLASTP
28299982830249252hypothetical proteinBLASTP
28302882830527240hypothetical proteinBLASTP
283133628332521917putaive autotransporter proteinQuickGO ontologyBLASTP
28337872834368582hypothetical proteinBLASTP
28343832834691309hypothetical proteinBLASTP
283477028359781209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
28362332836394162hypothetical proteinBLASTP
283643028386372208hypothetical proteinBLASTP
28386302839160531hypothetical proteinBLASTP
283931928417002382putative beta-glucosidaseQuickGO ontologyBLASTP
284177928434071629hypothetical proteinBLASTP