Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2785830 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
278583027868521023transposase for insertion sequence IS100QuickGO ontologyBLASTP
27868522787631780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
278809027892921203putative penicillin-binding protein 5QuickGO ontologyBLASTP
27894902789753264hypothetical proteinBLASTP
27899652790666702lipoate-protein ligase BQuickGO ontologyBLASTP
27908592791824966lipoic acid synthetaseQuickGO ontologyBLASTP
27920052792262258sec-independent protein translocase proteinQuickGO ontologyBLASTP
27928292793212384hypothetical proteinBLASTP
27936352793844210putative cold shock proteinQuickGO ontologyBLASTP
27941112794602492hypothetical proteinBLASTP
27949022795519618putative LuxR-family regulatory proteinsQuickGO ontologyBLASTP
27960532796907855hypothetical proteinBLASTP
27969842797271288hypothetical proteinBLASTP
27972892797483195hypothetical proteinBLASTP
27979262798213288hypothetical proteinBLASTP
279822928000191791putative ABC transport proteinQuickGO ontologyBLASTP
28000842800386303hypothetical proteinBLASTP
28005892801404816hypothetical proteinBLASTP
280141428024721059hypothetical proteinBLASTP
28024872803257771putative carbohydrate kinaseQuickGO ontologyBLASTP
280319928043201122putative carbohydrate kinaseQuickGO ontologyBLASTP
280435228054851134hypothetical proteinBLASTP
280550928065371029sugar transport system permease proteinQuickGO ontologyBLASTP
280654928080961548sugar transport ATP-binding proteinQuickGO ontologyBLASTP