Pre_GI Gene

Some Help

Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2681327 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
268132726830451719urease alpha subunitQuickGO ontologyBLASTP
26833412684036696urease accessory proteinQuickGO ontologyBLASTP
26840582684744687urease accessory proteinQuickGO ontologyBLASTP
26848712685533663urease accessory proteinQuickGO ontologyBLASTP
26855302686363834hypothetical proteinBLASTP
26863892686496108urease accessory proteinQuickGO ontologyBLASTP
26866882687680993putative urea transporterQuickGO ontologyBLASTP
268782926888871059putative nickel transport proteinQuickGO ontologyBLASTP
26890562689385330hypothetical proteinBLASTP
269000326911781176putative potassium channel proteinQuickGO ontologyBLASTP
26912762691680405hypothetical proteinBLASTP
26916962692076381hypothetical proteinBLASTP
26921652692344180hypothetical proteinBLASTP
26931172693434318PTS system cellobiose-specific IIB componentQuickGO ontologyBLASTP
269344526948061362PTS system cellobiose-specific IIC componentQuickGO ontologyBLASTP
26949732695320348PTS system cellobiose-specific IIA componentQuickGO ontologyBLASTP
26953692696199831cel operon repressorQuickGO ontologyBLASTP
26962512697012762hypothetical proteinBLASTP
26973072697675369hypothetical proteinBLASTP
26981702698697528putative negative regulator of replication initiationQuickGO ontologyBLASTP
269872827004131686phosphoglucomutaseQuickGO ontologyBLASTP
27006312700744114hypothetical proteinBLASTP
27007872701029243hypothetical proteinBLASTP
27011572701585429hypothetical proteinBLASTP
27016802702309630two-component regulatory protein response regulator KdpEQuickGO ontologyBLASTP
270260227053282727two-component regulatory protein sensor kinase KdpDQuickGO ontologyBLASTP