Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2599661 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
259966126006981038putative DNA-binding proteinQuickGO ontologyBLASTP
26006882601437750putative fimbrial biogenesis proteinQuickGO ontologyBLASTP
260159126027871197hypothetical proteinBLASTP
26030492603477429nucleoside diphosphate kinaseQuickGO ontologyBLASTP
260380426062242421hypothetical proteinBLASTP
26063992606656258hypothetical protein
260694026113164377putative autotransporter proteinQuickGO ontologyBLASTP
261187426150323159hypothetical proteinBLASTP
26149982615318321hypothetical proteinBLASTP
26156562616609954hypothetical proteinBLASTP
261668826179861299peptidase BQuickGO ontologyBLASTP
26181262618326201hypothetical proteinBLASTP
26183562618691336adrenodoxin family ferredoxinQuickGO ontologyBLASTP
261869426206461953chaperone protein HscAQuickGO ontologyBLASTP
26208892621413525chaperone protein HscBQuickGO ontologyBLASTP
26215242621847324hypothetical proteinBLASTP