Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2574794 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
257479425761881395putative proteaseQuickGO ontologyBLASTP
25768242577714891putative diacylglycerol kinaseQuickGO ontologyBLASTP
25780012578510510hypothetical proteinBLASTP
25787412578911171hypothetical proteinBLASTP
25788832579629747hypothetical proteinBLASTP
25796912580491801putative phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
25810132581480468hypothetical proteinBLASTP
25815392581817279hypothetical proteinBLASTP
258182925830371209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
25830622583763702hypothetical proteinBLASTP
25837602584155396hypothetical proteinBLASTP
25842192584614396hypothetical proteinBLASTP
25846762585071396hypothetical proteinBLASTP
25851352585533399hypothetical proteinBLASTP
25855572586036480hypothetical proteinBLASTP
25861962586369174transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
25863662586635270putative transposaseQuickGO ontologyBLASTP
258701025885871578putative GMP synthaseQuickGO ontologyBLASTP
258876725902301464inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
259040025917791380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
25922092593165957hypothetical proteinBLASTP
259351225949991488putative GTP-binding proteinQuickGO ontologyBLASTP
259514725963281182putative lipoproteinQuickGO ontologyBLASTP