Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2451872 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
245187224532211350putative two-component system sensor kinaseQuickGO ontologyBLASTP
24532472453930684putative two-component system response regulatorQuickGO ontologyBLASTP
245411824553231206putative HlyD family secretion proteinQuickGO ontologyBLASTP
245532724573632037putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
245761824592641647putative pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
245932424607841461putative permeaseQuickGO ontologyBLASTP
246112124621521032putative peptidaseQuickGO ontologyBLASTP
24621492462340192hypothetical proteinBLASTP
246237424635551182putative aminotransferaseQuickGO ontologyBLASTP
246425524656731419hypothetical proteinBLASTP
246590624674501545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
24674472468154708putative two-component response regulatorQuickGO ontologyBLASTP
246853524697671233hypothetical proteinBLASTP
24700122470890879cysteine synthase BQuickGO ontologyBLASTP
247106124721521092sulfate transport ATP-binding proteinQuickGO ontologyBLASTP
24721422473017876sulfate transport system permease protein CysWQuickGO ontologyBLASTP
24730172473850834sulfate transport system permease protein CysTQuickGO ontologyBLASTP
247385024748871038thiosulfate-binding proteinQuickGO ontologyBLASTP