Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2207198 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
220719822082531056hypothetical proteinBLASTP
22084002209224825sugar ABC transporter permease proteinQuickGO ontologyBLASTP
22092252210100876sugar ABC transporter permease proteinQuickGO ontologyBLASTP
221020922114951287putative solute-binding proteinQuickGO ontologyBLASTP
221176722128071041LacI-family transcriptional regulatory proteinQuickGO ontologyBLASTP
221282422142121389phosphomannomutaseQuickGO ontologyBLASTP
221431222153911080putative mannitol transport ATP-binding proteinQuickGO ontologyBLASTP
22155192215644126hypothetical proteinBLASTP
22156562216186531hypothetical proteinBLASTP
22164592216956498hypothetical proteinBLASTP
22170112217415405hypothetical proteinBLASTP
22175572217724168hypothetical proteinBLASTP
22179272218124198hypothetical proteinBLASTP
221813422201672034hypothetical proteinBLASTP
22208312221082252hypothetical proteinBLASTP
22213272221836510hypothetical proteinBLASTP
222183822293857548putative hemolysinQuickGO ontologyBLASTP
222958922312771689putative hemolysin activator proteinQuickGO ontologyBLASTP