Pre_GI Gene

Some Help

Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:2173708 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
217370821747541047dihydroorotaseQuickGO ontologyBLASTP
21750672175312246DNA-damage-inducible protein IQuickGO ontologyBLASTP
21758182176114297hypothetical proteinBLASTP
21760772176604528putative transposaseQuickGO ontologyBLASTP
21764742177286813putative transposaseQuickGO ontologyBLASTP
217764721787621116putative sarcosine oxidaseQuickGO ontologyBLASTP
217920721804151209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
21805442180936393putative LuxR-family regulatory proteinQuickGO ontologyBLASTP
218150821825661059hypothetical proteinBLASTP
21827152183500786hypothetical proteinBLASTP
21835792183782204hypothetical proteinBLASTP
21841412184545405hypothetical proteinBLASTP
21846352184796162hypothetical proteinBLASTP
21848332185510678hypothetical proteinBLASTP
21859412186585645N-acylhomoserine lactone synthase YpeIQuickGO ontologyBLASTP
21865782187315738quorum-sensing transcriptional activator YpeRQuickGO ontologyBLASTP
21878022188728927putative LysR-family transcriptional regulatorQuickGO ontologyBLASTP
218917621905341359putative transporter proteinQuickGO ontologyBLASTP
21905812191084504hypothetical proteinBLASTP
219109521921141020putative oxidoreductaseQuickGO ontologyBLASTP
21921922192746555hypothetical proteinBLASTP
219275721937611005hypothetical proteinBLASTP
21937792194729951hypothetical proteinBLASTP
219472621960721347hypothetical proteinBLASTP