Pre_GI Gene

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Host: NC_008150 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008150:1705152 Yersinia pestis Antiqua, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17051521705703552putative nitroreductaseQuickGO ontologyBLASTP
170592817069741047selenide water dikinaseQuickGO ontologyBLASTP
170703317089611929DNA topoisomerase IIIQuickGO ontologyBLASTP
17089581709248291hypothetical proteinBLASTP
17092611709647387putative pyrophosphohydrolaseQuickGO ontologyBLASTP
17097451710551807exodeoxyribonuclease IIIQuickGO ontologyBLASTP
17113611712221861putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
1712729171281385tRNA-TyrQuickGO ontologyBLASTP
171309317143011209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
17142641715133870hypothetical proteinBLASTP
17152171715681465hypothetical proteinBLASTP
171701517180311017response regulatorQuickGO ontologyBLASTP
171833817196841347putative nucleotide sugar dehydrogenaseQuickGO ontologyBLASTP
17201191720517399DNA-binding protein HnsQuickGO ontologyBLASTP
17212671721857591thymidine kinaseQuickGO ontologyBLASTP
17222261723005780insertion sequence IS100 ATP-binding proteinQuickGO ontologyBLASTP
172300517240271023transposase for insertion sequence IS100QuickGO ontologyBLASTP
172456717272422676aldehyde-alcohol dehydrogenaseQuickGO ontologyBLASTP
17280491728693645hypothetical proteinBLASTP
172953117311681638periplasmic oligopeptide-binding protein precursorQuickGO ontologyBLASTP
17312551732175921oligopeptide transport system permease proteinQuickGO ontologyBLASTP
17321941733099906oligopeptide transport system permease proteinQuickGO ontologyBLASTP
173311117341121002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
173410917351101002oligopeptide transport ATP-binding proteinQuickGO ontologyBLASTP
17356711735886216hypothetical proteinBLASTP
17361851736538354hypothetical proteinBLASTP
173667317381331461cardiolipin synthetaseQuickGO ontologyBLASTP
17391801739719540attachment invasion locus protein precursorQuickGO ontologyBLASTP
17396941739822129hypothetical proteinBLASTP
17399401740203264hypothetical proteinBLASTP
17403191740564246hypothetical proteinBLASTP
17407871741083297hypothetical proteinBLASTP
17413841742142759TonB proteinQuickGO ontologyBLASTP
174217817433861209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
17435341743983450putative acyl-CoA thioester hydrolaseQuickGO ontologyBLASTP
17440631744605543putative intracellular septation proteinQuickGO ontologyBLASTP